GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11723261 | 1 | rs6599318 | chr4:243968 | ZNF718 | chr4:53272-156488:+ | 0.51 | 9.45 | 1.46E-19 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs2721195 | 1 | rs6599530 | chr8:145677418 | KIFC2 | chr8:145691738-145699498:+ | -0.13 | -3.97 | 8.36E-5 | Age at first birth |
| THCA | cis | rs2721195 | 1 | rs6599530 | chr8:145677418 | LRRC14 | chr8:145743391-145750557:+ | 0.18 | 5.11 | 4.66E-7 | Age at first birth |
| THCA | cis | rs2721195 | 1 | rs6599530 | chr8:145677418 | RECQL4 | chr8:145736672-145743200:- | 0.16 | 3.57 | 0.000399 | Age at first birth |
| THCA | cis | rs2721195 | 1 | rs6599530 | chr8:145677418 | ZNF34 | chr8:145998503-146012725:- | 0.15 | 3.81 | 0.000155 | Age at first birth |
| THCA | cis | rs7069346 | 1 | rs6599639 | chr10:124743751 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.01 | 7.03E-5 | Migraine without aura |
| THCA | cis | rs507080 | 1 | rs659969 | chr11:118549803 | TREH | chr11:118528942-118550381:- | 0.48 | 9.71 | 1.81E-20 | Serum metabolite levels |
| THCA | cis | rs6686842 | 1 | rs6600365 | chr1:41556253 | SCMH1 | chr1:41492875-41707788:- | 0.2 | 4.72 | 3.09E-6 | Height |
| THCA | cis | rs6600671 | 1 | rs6600669 | chr1:121213639 | HIST2H2BA | chr1:120906034-120914842:+ | 0.21 | 4.86 | 1.57E-6 | Hip geometry |
| THCA | cis | rs6600671 | 1 | rs6600671 | chr1:121200490 | HIST2H2BA | chr1:120906034-120914842:+ | -0.18 | -4.04 | 6.29E-5 | Hip geometry |
| THCA | cis | rs6982751 | 1 | rs6601540 | chr8:10816873 | CTSB | chr8:11700036-11725646:- | 0.21 | 3.36 | 0.000834 | Asthma and hay fever |
| THCA | cis | rs6602175 | 1 | rs6602175 | chr10:17142526 | CUBN | chr10:16865966-17171816:- | 0.21 | 4.89 | 1.4E-6 | Whole-brain volume |
| THCA | cis | rs8030379 | 1 | rs6603003 | chr15:84565602 | LOC388152 | chr15:84867600-84898920:- | -0.21 | -3.9 | 0.000111 | Waist circumference adjusted for body mass index;Waist circumference |
| THCA | cis | rs8030379 | 1 | rs6603004 | chr15:84568504 | LOC388152 | chr15:84867600-84898920:- | 0.2 | 3.82 | 0.000153 | Waist circumference adjusted for body mass index;Waist circumference |
| THCA | cis | rs783540 | 1 | rs6603033 | chr15:83335875 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | 0.14 | 4.23 | 2.76E-5 | Schizophrenia |